PhenoAge calculator
Computes Levine Phenotypic Age (2018) from standard blood panel values. Formula and coefficients are published and unchanged since 2018 — see the PhenoAge method page for the original citation.
Choose the unit printed on your laboratory report for each blood-chemistry value. Conversion is automatic. Changing a unit keeps the number you entered, so check that both match your report. WBC 10⁹/L has the same numeric value as 1000 cells/µL. Use RDW-CV (%), not RDW-SD (fL), and lymphocyte percent, not an absolute count. All fields start empty. “Try example” fills a fictional example, not your results.
Paste lab results
Paste plain text with one test per line, for example “Albumin 45 g/L”. English test names and common abbreviations are supported. Every value needs an explicit unit; reference ranges alone, inequalities and duplicate results are not imported. No text is uploaded or stored by this site.
Check the detected values against your report. Filling these values replaces the current panel and clears missing fields and age. Nothing is calculated automatically.
This calculator implements the published Levine et al. 2018 formula directly in your browser. Your laboratory values, age, pasted text and result stay in your browser. We count successful calculations without sending those values. Privacy details. This is not medical advice.
The published calculation
After conversion: albumin in g/L, creatinine in µmol/L, glucose in mmol/L and CRP in mg/dL. ln means natural logarithm. For positive CRP below 0.01 mg/L, this calculator uses 0.01 mg/L; a report such as <0.1 is not an exact value.
xb = -19.90667 + (-0.03359355) × albumin + 0.009506491 × creatinine + 0.1953192 × glucose + 0.09536762 × ln(CRP) + (-0.01199984) × lymphocyte % + 0.02676401 × MCV + 0.3306156 × RDW + 0.001868778 × ALP + 0.05542406 × WBC + 0.08035356 × chronological age M = 1 − exp(−1.51714 × exp(xb) / 0.007692696) PhenoAge = 141.50225 + ln(-0.0055305 × ln(1 − M)) / 0.090165
The browser evaluates the algebraically equivalent log-space expression to avoid rounding M to 1 at extreme inputs. Original study and units (Table 1) · Reference coefficients.
PhenoAge vs GrimAge: inputs, meaning and limitations
Limitations
- Coefficients were derived from US NHANES populations; generalizability outside those populations is not established by the original study.
- PhenoAge is a Gompertz mortality-risk model fitted to nine clinical biomarkers and chronological age, not a direct biological measurement of aging.
- Results are sensitive to laboratory methods, reference ranges and the exact units entered.
- Clinical PhenoAge is distinct from DNAm PhenoAge, an epigenetic clock trained to predict the phenotypic score from blood DNA methylation.
Compare biological-age methods
PhenoAge (Levine Phenotypic Age)
blood-based- Published
- 2018
- Sample/input
- blood (serum/plasma, routine CBC + chemistry panel)
- Output
- PhenoAge (years); Phenotypic Age Advancement (PhenoAge minus chronological age)
- Public coefficients
- Clinical PhenoAge (Phenotypic Age): Published
GrimAge
epigenetic- Published
- 2019
- Sample/input
- blood (DNA methylation, Illumina array)
- Output
- GrimAge (years); DNAm-based mortality risk estimate
- Public coefficients
- GrimAge version 1: Published; GrimAge version 2: Published
DunedinPACE
epigenetic- Published
- 2022
- Sample/input
- blood (DNA methylation, Illumina array)
- Output
- Pace of aging (ratio; 1.0 = one year of biological aging per calendar year)
- Public coefficients
- DunedinPACE: Published
Klemera-Doubal Biological Age (KDM)
blood-based- Published
- 2006
- Sample/input
- blood (routine chemistry panel; panel composition varies by implementation)
- Output
- Biological age (years)
- Public coefficients
- Klemera-Doubal method (2006 framework): Not applicable
GlycanAge
blood-based- Published
- 2014
- Sample/input
- blood (plasma IgG N-glycans; UPLC in the 2014 study)
- Output
- Research index: predicted age from three IgG glycan peaks with sex-specific equations. The commercial test reports its own indices (see products).
- Public coefficients
- Glycan age index (research model, 2014): Published; Algorithm of the GlycanAge test as marketed: Unresolved
- Published
- 2023
- Sample/input
- retina (fundus image)
- Output
- Retinal age; retinal age gap (retinal age minus chronological age)
- Public coefficients
- Retinal age gap (UK Biobank deep-learning model, 2023): Unresolved